KLOTHO; RBX-50UG

Code: AB15504 D2-231

Application

Detect Klotho using this Anti-Klotho Antibody validated for use in ELISA & WB.

General description

Animal models of human aging, whic...


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€507.00 EACH
€623.61 inc. VAT

Application

Detect Klotho using this Anti-Klotho Antibody validated for use in ELISA & WB.

General description

Animal models of human aging, which display the characteristic diseases associated with aging, provide insight into the cause of such diseases. Recently a transgenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of genital organs and thymus, emphysema and short life span (Kuro-o et al., 1997). KL protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane (Martin & Mian, 1997). The extracellular domain has two internal repeats, KL-1 and KL-2 which have 20-40% sequence identity to bacterial b-glucosidase of plants and animals and mammalian lactase glycosylceramidase suggesting a role for Klotho in sphingolipid metabolism (Martin & Mian, 1997). kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway. KL has been reported to be localized on the cell surface when expressed on Cho cells (Kuro-o et al., 1997). Human kl cDNA is expected to encode a protein of 1012 amino acids and has 86% homology to mouse kl.

Immunogen

Synthetic peptide near the C-terminus of mouse Klotho.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Specificity

Klotho

Other species have not yet been tested. The immunogen sequence is 82% conserved in human and 76% in rat klotho.

antibody formaffinity isolated antibody
antibody product typeprimary antibodies
biological sourcerabbit
clonepolyclonal
Gene Informationhuman ... KL(9365)
manufacturer/tradenameChemicon®
NCBI accession no.NM_004795.2, NM_153683.2
purified byaffinity chromatography
Quality Level100
shipped indry ice
species reactivitymouse
technique(s)western blot: suitable, ELISA: suitable
UniProt accession no.Q9UEF7
This product has met the following criteria to qualify for the following awards:



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